No — Johnny Knoxville's handedness is currently unknown, as no reliable public source confirms whether he is left-handed, right-handed, or mixed-handed.

Johnny Knoxville, born Philip John Clapp, is an American actor, comedian, stunt performer, and filmmaker. He is best known as the co-creator and star of the MTV reality stunt show Jackass, which premiered in 2000.

Knoxville's career began with him pitching article ideas to magazines, one of which involved testing self-defense equipment on himself. This concept evolved into the pilot for Jackass, which quickly gained a massive following for its outrageous and dangerous stunts.

Following the success of Jackass, Knoxville starred in several feature films based on the show, including "Jackass: The Movie," "Jackass Number Two," "Jackass 3D," and "Jackass Forever." He also pursued acting roles in more traditional films.

His acting credits include roles in movies such as "Men in Black II," "Walking Tall," "The Dukes of Hazzard," "Bad Grandpa," and "Elvis & Nixon." Knoxville continues to be a prominent figure in entertainment, known for his daring personality.