No — there is no reliable public source that currently confirms Giuliana Rancic is left-handed. Based on available public information, her handedness remains unconfirmed.

Giuliana Rancic (née DePandi) is an American entertainment reporter, television personality, and businesswoman. Born in Naples, Italy, she moved to the United States with her family at a young age.

She is widely recognized for her long tenure as a co-anchor on E! News, a role she held for over a decade. Rancic also frequently hosted red carpet events for major award shows, interviewing countless celebrities.

Beyond her television career, Rancic has ventured into business, including fashion and wine. She is also a breast cancer survivor and advocate, openly sharing her journey to raise awareness.

Rancic is married to entrepreneur Bill Rancic, whom she met while he was a contestant on 'The Apprentice.' The couple has one child together and has appeared in their own reality television series, 'Giuliana and Bill.'